Available Definitions:
1) a. - Pain of mind on account of something in the past; mental suffering arising from any cause, as misfortune, loss of friends, misconduct of one's self or others, etc.; sorrow; sadness.
2) a. - Cause of sorrow or pain; that which afficts or distresses; trial; grievance.
3) a. - Physical pain, or a cause of it; malady.