Available Definitions:
1) n. - Malice; malignity; spite; malicious anger; contemptuous hate.
2) n. - An act of malice, hatred, or defiance; contemptuous defiance; a deed of contempt.
3) n. - To vex; to annoy; to offend contemptuously.
4) prep. - In spite of; against, or in defiance of; notwithstanding; as, despite his prejudices.